Post-doctoral positions at Columbia University: In-vivo Microscopy and Molecular Imaging
Columbia University in the City of New York, New York,
United States
Two post-doctoral positions are available for immediate
start in the laboratory of Dr Elizabeth Hillman. Our lab develops and then
applies advanced in-vivo optical imaging and microscopy technologies to gain
insight into the function of living tissue, organs and organisms. The following
positions are available on two separate projects:
1) Neuroimaging: In-vivo microscopy and optical imaging
of brain function
Using rodent models, we are exploring the interrelation
between blood flow and neuronal activity in the living intact brain. We combine
high-speed camera imaging of the exposed cortex with multispectral in-vivo
two-photon microscopy to animate the neurovascular coupling process via calcium
sensitive dyes, transgenic fluorescent proteins and hemoglobin absorption
dynamics. We are seeking a post-doctoral fellow to conduct a range of
experiments utilizing these tools to investigate neurovascular coupling and its
underlying relation to cortical metabolism. Candidates will ideally have a
neuroscience background and experience / interest in advanced imaging and
microscopy, or alternatively; strong optical engineering and microscopy
development experience and an established interest in neuroscience. Matlab
programming skills and data analysis expertise would be a significant
advantage. fMRI experience would be valuable but is not required.
2) Small Animal Molecular Imaging
We are developing a new small animal imaging technology for
drug discovery and disease research known as ‘Dynamic Contrast Enhancement’
(DyCE) for Molecular Imaging. This technique investigates the dynamics of
fluorescent dyes injected into the tail vein of a mouse during high-speed
imaging. Recently featured on the cover of Nature Photonics, this method has
the potential to have significant impact on current small animal imaging
practices. We are seeking a post-doctoral fellow to conduct research related to
DyCE to investigate and develop broader applications for the technique, and to
collaborate with local researchers on implementing and evaluating the technique
for specific biomedical targets. Candidates will ideally have well-rounded
experience in imaging, data acquisition and data analysis, as well as
experience working with rodents. Interest and experience in biochemistry and
molecular probe development would be a advantage, as would an established track
record of performing well on collaborative and interdisciplinary research
projects.
Candidates for both positions should be highly motivated and
skilled at working in amicable, energetic, interdisciplinary teams. Positions
will be based at Columbia’s Morningside Campus in upper Manhattan, New York.
Women and minority candidates are encouraged to apply, as are international
scholars. Applicants should provide a copy of their CV and a brief statement of
their research interests. For more information on our lab and project please
visit: www.bme.columbia.edu/~hillman
or contact Elizabeth Hillman directly at: eh2245@columbia.edu
*************************************************
Elizabeth M. C. Hillman PhD.
Assistant Professor
Department of Biomedical Engineering
Columbia University
351L Engineering Terrace
1210 Amsterdam Ave
New York, NY 10027
Phone: 212-854-2788
Fax: 212-854-8725
eh2245@columbia.edu
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